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Statistics
241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last update: 11 Mar, 2019
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last update: 11 Mar, 2019
Top
KEGG Pathway - Cholinergic synapse - Homo sapiens (human) 
 | Phosphatases regulating this pathway |
Phosphatases regulating this pathway are unknown (yet)
| Protein substrates in this pathway |
| Name | UniProt AC | Dephosphorylated by: |
| JAK2 | O60674 | PTPRC, PTPN1, PTPN6, PTPN11, |
| PRKCB | P05771 | PHLPP1, PHLPP2, PPP1CA, PPP2CA, PPP2CB, |
| FYN | P06241 | PTPRC, PTPN18, PTPRA, PTPRE, PTPRJ, PTPN5, |
| BCL2 | P10415 | PPP2CA, PPP2CB, |
| CREB1 | P16220 | PPP2CA, PPP2CB, PTEN, |
| PRKCA | P17252 | PHLPP1, PHLPP2, PPP1CA, PPP1CB, PPP1CC, PPP2CA, PPP2CB, |
| PRKACA | P17612 | PPP2CA, PPP2CB, |
| MAPK3 | P27361 | CDC25A, DUPD1, PTPN7, DUSP5, DUSP1, DUSP4, DUSP9, DUSP23, PTPRE, PTPRJ, DUSP3, PPP2CA, PTPRR, DUSP14, |
| PIK3R1 | P27986 | PPM1A, PTPRJ, |
| MAPK1 | P28482 | CDC25A, DUSP22, DUPD1, PTPN7, DUSP5, DUSP1, DUSP4, DUSP6, DUSP9, DUSP7, DUSP2, PPP2CA, PPP2CB, PTPRE, PTPRJ, DUSP3, PTPRR, |
| AKT1 | P31749 | ACP1, PHLPP1, PHLPP2, PPP2CA, PPP2CB, PPP1CA, PPP1CB, PPP1CC, CTDSP1, |
| AKT2 | P31751 | PHLPP1, PHLPP2, |
| GNB1 | P62873 | PHPT1, |
| MAP2K1 | Q02750 | PPP2CA, PPP2CB, |
| CAMK2B | Q13554 | PPP2CA, PPP2CB, |
| CAMK2G | Q13555 | PPP1CA, PPP1CB, PPP1CC, PPP2CA, PPP2CB, CTDSPL, |
| CAMK4 | Q16566 | PPM1F, PPM1E, PPP2CA, PPP2CB, |
| CAMK2A | Q9UQM7 | PPM1F, PPP1CA, PPP1CB, PPP1CC, PPP2CA, PPP2CB, |
| AKT3 | Q9Y243 | PHLPP1, PHLPP2, PPP2CA, PPP2CB, |
| Non-protein substrates in this pathway |
| ChEBI ID | KEGG ID | ChEBIasciiName | Molecule | Dephosphorylated by: |
| CHEBI:16595 | C01245 | 1D-myo-inositol 1,4,5-trisphosphate |  | INPP5B, INPP5A, INPP5E, INPP5J, INPP5K, OCRL, SYNJ1, SYNJ2, |
| CHEBI:18348 | C04637 | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate |  | FIG4, INPP5B, INPP5E, INPP5J, INPP5K, OCRL, PTP4A3, PTPRQ, INPP5F, SYNJ1, SYNJ2, |