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Statistics
241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last update: 11 Mar, 2019
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last update: 11 Mar, 2019
Top
USP6NL
Gene Name  | USP6NL (QuickGO) | (A quick tutorial to explore the interctive visulaization) Representative structure: NA |
| Synonyms | USP6NL, KIAA0019 | |
| Protein Name | USP6NL | |
| Alternative Name(s) | USP6 N-terminal-like protein;Related to the N-terminus of tre;RN-tre; | |
| Protein Family | noSimilarity_annotations | |
| EntrezGene ID | 9712 (Comparitive Toxicogenomics) | |
| UniProt AC (Human) | Q92738 (protein sequence) | |
| Enzyme Class | N/A | |
| Molecular Weight | 94104 Dalton | |
| Protein Length | 828 amino acids (AA) | |
| Genome Browsers | NCBI | ENSG00000148429 (Ensembl) | UCSC | 1000 Genomes | |
| Crosslinking annotations | Query our ID-mapping table | |
| Orthologues | Quest For Orthologues (QFO) | GeneTree | eggNOG - KOG1102 | eggNOG - COG5210 | |
| Phosphorylation Network | Visualize | |
| Domain organization, Expression, Diseases | (show / hide) |
| Protein Domain | InterPro | Pfam | SMART | 3D Structure | PDB | DrugPort | ModBase | SwissModel |
| Polypeptide organization (Pfam) | No Pfam domain found | ||
| Gene Expression | Gene Expression Atlas | Disease | OMIM | COSMIC | ClinVar |
| Protein-protein interactions | STRING | IntAct | MINT | BioGRID | ||
| Phosphosites | Phospho.ELM | PhosphoSitePlus | ||
| Localization, Function, Catalytic activity and Sequence | (show / hide) |
| Localization (UniProt annotation) | |||
| Golgi apparatus Cytoplasmic vesicle | |||
| Function (UniProt annotation) | |||
| Acts as a GTPase-activating protein for RAB5A and RAB43Involved in receptor trafficking In complex with EPS8 inhibitsinternalization of EGFR Involved in retrograde transport from theendocytic pathway to the Golgi apparatus Involved in thetransport of Shiga toxin from early and recycling endosomes to thetrans-Golgi network Required for structural integrity of theGolgi complex | |||
| Catalytic Activity (UniProt annotation) | |||
| N/A | |||
| Protein Sequence | |||
| MNSDQDVALKLAQERAEIVAKYDRGREGAEIEPWEDADYLVYKVTDRFGFLHEEELPDHNVAVERQKHLEIERTTKWLKM LKGWEKYKNTEKFHRRIYKGIPLQLRGEVWALLLEIPKMKEETRDLYSKLKHRARGCSPDIRQIDLDVNRTFRDHIMFRD RYGVKQQSLFHVLAAYSIYNTEVGYCQGMSQITALLLMYMNEEDAFWALVKLFSGPKHAMHGFFVQGFPKLLRFQEHHEK ILNKFLSKLKQHLDSQEIYTSFYTMKWFFQCFLDRTPFTLNLRIWDIYIFEGERVLTAMSYTILKLHKKHLMKLSMEELV EFFQETLAKDFFFEDDFVIEQLQISMTELKRAKLDLPEPGKEDEYPKKPLGQLPPELQSWGVHHLSNGQRSVGRPSPLAS GRRESGAPHRRHEHSPHPQSRTGTPERAQPPRRKSVEEESKKLKDEADFQRKLPSGPQDSSRQYNHAAANQNSNATSNIR KEFVPKWNKPSDVSATERTAKYTMEGKGRAAHPALAVTVPGPAEVRVSNVRPKMKALDAEDGKRGSTASQYDNVPGPELD SGASVEEALERAYSQSPRHALYPPSPRKHAEPSSSPSKVSNKFTFKVQPPSHARYPSQLDGEARGLAHPPSYSNPPVYHG NSPKHFPTANSSFASPQFSPGTQLNPSRRPHGSTLSVSASPEKSYSRPSPLVLPSSRIEVLPVDTGAGGYSGNSGSPKNG KLIIPPVDYLPDNRTWSEVSYTYRPETQGQSWTRDASRGNLPKYSAFQLAPFQDHGLPAVSVDSPVRYKASPAAEDASPS GYPYSGPPPPAYHYRNRDGLSIQESVLL | |||
| Motif information from Eukaryotic Linear Motif atlas (ELM) | (show / hide) |
ELM Motif | Motif Instance | Description | Motif Regex |
| LIG_SH3_5 | 725-PPVDY-729 | SH3 ligand | P..DY |
| Gene Ontology (P: Process; F: Function and C: Component terms) | (show / hide) | |
| GO:0005096 | F:GTPase activator activity |
| GO:0005829 | C:cytosol |
| GO:0005886 | C:plasma membrane |
| GO:0006886 | P:intracellular protein transport |
| GO:0007030 | P:Golgi organization |
| GO:0012505 | C:endomembrane system |
| GO:0017137 | F:Rab GTPase binding |
| GO:0019068 | P:virion assembly |
| GO:0031338 | P:regulation of vesicle fusion |
| GO:0031410 | C:cytoplasmic vesicle |
| GO:0032588 | C:trans-Golgi network membrane |
| GO:0035526 | P:retrograde transport |
| GO:0043547 | plasma membrane to Golgi |
| GO:0048227 | P:positive regulation of GTPase activity |
| GO:0090630 | P:plasma membrane to endosome transport |
| GO:1903358 | P:activation of GTPase activity |
