DEPOD - human DEPhOsphorylation Database

Name	1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate	Download: mol \| sdf
Synonyms	01,2-diacyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4'-bisphosphate); 1-phosphatidyl-1d-myo-inositol 3,4-bisphosphate; 1-phosphatidyl-1d-myo-inositol 3,4-bisphosphate pentaanion; Na; Pi(3,4)p2; Pips; Ptdins(3,4)p2;
Definition	NA
Molecular Weight (Exact mass)	NA
Molecular Formula	C11H19O19P3R2
SMILES	[H][C@@](COC([])=O)(COP(O)(=O)O[C@H]1[C@H](O)[C@@H](O)[C@H](OP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H]1O)OC([])=O
InChI	InChI=1S/C6H16O18P4/c7-1-2(8)4(22-26(12,13)14)6(24-28(18,19)20)5(23-27(15,16)17)3(1)21-25(9,10)11/h1-8H,(H2,9,10,11)(H2,12,13,14)(H2,15,16,17)(H2,18,19,20)/t1-,2+,3-,4-,5+,6+/m1/s1
InChI Key	MRVYFOANPDTYBY-YORTWTKJSA-N
Crosslinking annotations	KEGG:C11554 \| ChEBI:16152 \| PubChem:13721

Pathway ID	Pathway Name	Pathway Description (KEGG)
map00562	Inositol phosphate metabolism	NA
map01100	Metabolic pathways	NA
map04070	Phosphatidylinositol signaling system	NA
map04810	Regulation of actin cytoskeleton	NA
map04914	Progesterone-mediated oocyte maturation	Xenopus oocytes are naturally arrested at G2 of meiosis I. Exposure to either insulin/IGF-1 or the steroid hormone progesterone breaks this arrest and induces resumption of the two meiotic division cycles and maturation of the oocyte into a mature, fertilizable egg. This process is termed oocyte maturation. The transition is accompanied by an increase in maturation promoting factor (MPF or Cdc2/cyclin B) which precedes germinal vesicle breakdown (GVBD). Most reports point towards the Mos-MEK1-ERK2 pathway [where ERK is an extracellular signal-related protein kinase, MEK is a MAPK/ERK kinase and Mos is a p42(MAPK) activator] and the polo-like kinase/CDC25 pathway as responsible for the activation of MPF in meiosis, most likely triggered by a decrease in cAMP.

CHEBI:16152