Top CTNND1
Localization (UniProt annotation) Cytoplasm Nucleus Cellmembrane Note=Interaction with GLIS2 promotesnuclear translocation (By similarity) Detected at cell-cellcontacts (PubMed:15240885, PubMed:17047063) NANOS1 induces itstranslocation from sites of cell-cell contact to the cytoplasm(PubMed:17047063) CDH1 enhances cell membrane localization(PubMed:15240885) Isoforms 4A and 1AB are excluded from thenucleus (PubMed:11896187) Isoform 1A: Nucleus Isoform 2A: Nucleus Isoform 3A: Nucleus Function (UniProt annotation) Binds to and inhibits the transcriptional repressorZBTB33, which may lead to activation of target genes of the Wntsignaling pathway (By similarity) Associates with and regulatesthe cell adhesion properties of both C-, E- and N-cadherins, beingcritical for their surface stability Implicated both in celltransformation by SRC and in ligand-induced receptor signalingthrough the EGF, PDGF, CSF-1 and ERBB2 receptors Promotes GLIS2C-terminal cleavage Catalytic Activity (UniProt annotation) N/A Protein Sequence MDDSEVESTASILASVKEQEAQFEKLTRALEEERRHVSAQLERVRVSPQDANPLMANGTLTRRHQNGRFVGDADLERQKF
SDLKLNGPQDHSHLLYSTIPRMQEPGQIVETYTEEDPEGAMSVVSVETSDDGTTRRTETTVKKVVKTVTTRTVQPVAMGP
DGLPVDASSVSNNYIQTLGRDFRKNGNGGPGPYVGQAGTATLPRNFHYPPDGYSRHYEDGYPGGSDNYGSLSRVTRIEER
YRPSMEGYRAPSRQDVYGPQPQVRVGGSSVDLHRFHPEPYGLEDDQRSMGYDDLDYGMMSDYGTARRTGTPSDPRRRLRS
YEDMIGEEVPSDQYYWAPLAQHERGSLASLDSLRKGGPPPPNWRQPELPEVIAMLGFRLDAVKSNAAAYLQHLCYRNDKV
KTDVRKLKGIPVLVGLLDHPKKEVHLGACGALKNISFGRDQDNKIAIKNCDGVPALVRLLRKARDMDLTEVITGTLWNLS
SHDSIKMEIVDHALHALTDEVIIPHSGWEREPNEDCKPRHIEWESVLTNTAGCLRNVSSERSEARRKLRECDGLVDALIF
IVQAEIGQKDSDSKLVENCVCLLRNLSYQVHREIPQAERYQEAAPNVANNTGPHAASCFGAKKGKDEWFSRGKKPIEDPA
NDTVDFPKRTSPARGYELLFQPEVVRIYISLLKESKTPAILEASAGAIQNLCAGRWTYGRYIRSALRQEKALSAIADLLT
NEHERVVKAASGALRNLAVDARNKELIGKHAIPNLVKNLPGGQQNSSWNFSEDTVISILNTINEVIAENLEAAKKLRETQ
GIEKLVLINKSGNRSEKEVRAAALVLQTIWGYKELRKPLEKEGWKKSDFQVNLNNASRSQSSHSYDDSTLPLIDRNQKSD
KKPDREEIQMSNMGSNTKSLDNNYSTPNERGDHNRTLDRSGDLGDMEPLKGTTPLMQDEGQESLEEELDVLVLDDEGGQV
SYPSMQKI
ELM Motif Motif Instance Description Motif Regex TRG_NES_CRM1_1 942-ESLEEELDVLVLDDE-956 NES Nuclear Export Signal ([DEQ].{0,1}[LIM].{2,3}[LIVMF][^P]{2,3}[LMVF].[LMIV].{0,3}[DE])|([DE].{0,1}[LIM].{2,3}[LIVMF][^P]{2,3}[LMVF].[LMIV].{0,3}[DEQ])
CTNND1 is dephosphorylated by following phosphatases:
Pathway ID Pathway Name Pathway Description (KEGG) hsa04015 Rap1 signaling pathway Rap1 is a small GTPase that controls diverse processes, such as cell adhesion, cell-cell junction formation and cell polarity. Like all G proteins, Rap1 cycles between an inactive GDP-bound and an active GTP-bound conformation. A variety of extracellular signals control this cycle through the regulation of several unique guanine nucleotide exchange factors (GEFs) and GTPase activating proteins (GAPs). Rap1 plays a dominant role in the control of cell-cell and cell-matrix interactions by regulating the function of integrins and other adhesion molecules in various cell types. Rap1 also regulates MAP kinase (MAPK) activity in a manner highly dependent on the context of cell types. hsa04520 Adherens junction Cell-cell adherens junctions (AJs), the most common type of intercellular adhesions, are important for maintaining tissue architecture and cell polarity and can limit cell movement and proliferation. At AJs, E-cadherin serves as an essential cell adhesion molecules (CAMs). The cytoplasmic tail binds beta-catenin, which in turn binds alpha-catenin. Alpha-catenin is associated with F-actin bundles directly and indirectly. The integrity of the cadherin-catenin complex is negatively regulated by phosphorylation of beta-catenin by receptor tyrosine kinases (RTKs) and cytoplasmic tyrosine kinases (Fer, Fyn, Yes, and Src), which leads to dissociation of the cadherin-catenin complex. Integrity of this complex is positively regulated by beta -catenin phosphorylation by casein kinase II, and dephosphorylation by protein tyrosine phosphatases. Changes in the phosphorylation state of beta-catenin affect cell-cell adhesion, cell migration and the level of signaling beta-catenin. Wnt signaling acts as a positive regulator of beta-catenin by inhibiting beta-catenin degradation, which stabilizes beta-catenin, and causes its accumulation. Cadherin may acts as a negative regulator of signaling beta-catenin as it binds beta-catenin at the cell surface and thereby sequesters it from the nucleus. Nectins also function as CAMs at AJs, but are more highly concentrated at AJs than E-cadherin. Nectins transduce signals through Cdc42 and Rac, which reorganize the actin cytoskeleton, regulate the formation of AJs, and strengthen cell-cell adhesion. hsa04670 Leukocyte transendothelial migration Leukocyte migaration from the blood into tissues is vital for immune surveillance and inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell adhesion molecules (CAM) and then migrate across the vascular endothelium. A leukocyte adherent to CAMs on the endothelial cells moves forward by leading-edge protrusion and retraction of its tail. In this process, alphaL /beta2 integrin activates through Vav1, RhoA, which subsequently activates the kinase p160ROCK. ROCK activation leads to MLC phosphorylation, resulting in retraction of the actin cytoskeleton. Moreover, Leukocytes activate endothelial cell signals that stimulate endothelial cell retraction during localized dissociation of the endothelial cell junctions. ICAM-1-mediated signals activate an endothelial cell calcium flux and PKC, which are required for ICAM-1 dependent leukocyte migration. VCAM-1 is involved in the opening of the endothelial passagethrough which leukocytes can extravasate. In this regard, VCAM-1 ligation induces NADPH oxidase activation and the production of reactive oxygen species (ROS) in a Rac-mediated manner, with subsequent activation of matrix metallopoteinases and loss of VE-cadherin-mediated adhesion.
Pathway ID Pathway Name Pathway Description (KEGG) R-HSA-418990 Adherens junctions interactions. The adherens junctions (AJ) are multiprotein complexes that promote homotypic cell adhesion in nearly all types of tissue by linking membrane and cytoskeletal components at discrete contact regions (reviewed in Hartsock & Nelson 2008; Gumbiner 2005; Ebnet, 2008). The molecular constituents of adherens junctions form adhesive units which are organized into higher order junctional adhesions that create a zipper-like seal between adjacent cells. Junctional adhesions function in epithelial cell polarization and in the coupling of cytoskeletons in adjacent cells that allow coordinated movements. During embryonic development, AJs function in specifying adhesion between cells and contribute in the sorting of different cell types. AJs also regulate cell polarity and shape, promote cell-cell communication and help mediate contact inhibition of cell growth. This module covers transdimerization events involving AJ transmembrane proteins (cadherins and nectins) (Gumbiner 2005; Ebnet 2008; Hartsock & Nelson 2008) R-HSA-5218920 VEGFR2 mediated vascular permeability. The free radical nitric oxide (NO), produced by endothelial NO synthase (eNOS), is an important vasoactive substance in normal vascular biology and pathophysiology. It plays an important role in vascular functions such as vascular dilation and angiogenesis (Murohara et al. 1998, Ziche at al. 1997). NO has been reported to be a downstream mediator in the angiogenic response mediated by VEGF, but the mechanism by which NO promotes neovessel formation is not clear (Babaei & Stewart 2002). Persistent vasodilation and increase in vascular permeability in the existing vasculature is observed during the early steps of angiogenesis, suggesting that these hemodynamic changes are indispensable during an angiogenic processes. NO production by VEGF can occur either through the activation of PI3K or through a PLC-gamma dependent manner. Once activated both pathways converge on AKT phosphorylation of eNOS, releasing NO (Lin & Sessa 2006). VEGF also regulates vascular permeability by promoting VE-cadherin endocytosis at the cell surface through a VEGFR-2-Src-Vav2-Rac-PAK signalling axis R-HSA-8876493 InlA-mediated entry of Listeria monocytogenes into host cells. The pathogenic bacteria Listeria monocytogenes can enter host cells through endocytosis triggered by binding of the bacterial cell wall protein internalin (InlA) to the E-cadherin (CDH1) complex at the host cell plasma membrane (Mengaud et al. 1996, Lecuit et al. 1999). Binding of InlA to CDH1, similar to CDH1 engagement during normal cell-to-cell adhesion, triggers activation of the SRC protein tyrosine kinase and phosphorylation of CDH1 and CDH1-bound beta-catenin (CTNNB1) (Fujita et al. 2002, McLachlan et al. 2007, Sousa et al. 2007, Bonazzi et al. 2008). Integrins likely contribute to CDH1-triggered SRC activation, and ERKs (MAPK1 and MAPK3), ROCKs and MLCK may also be involved (Avizienyte et al. 2002, Avizienyte et al. 2004, Martinez-Rico et al. 2010). FAK1 (PTK2), a SRC-regulated protein tyrosine kinase, may contribute to SRC-mediated regulation of CDH1 (Avizienyte et al. 2002).Phosphorylation of CDH1 and CTNNB1 by SRC creates docking sites for a CBL-like ubiquitin protein ligase Hakai (CBLL1). CBLL1 ubiquitinates SRC-phosphorylated CDH1 and CTNNB1 upon InlA binding, as well as in the context of CDH1-mediated cell-to-cell adhesion, thus triggering CDH1 endocytosis (Fujita et al. 2002, Bonazzi et al. 2008, Mukherjee et al. 2012).CBLL1 may also undergo SRC-mediated phosphorylation and subsequent autoubiquitination (Fujita et al. 2002).Both clathrin-mediated and caveolin-mediated endocytosis are implicated in the InlA-mediated entry of Listeria monocytogenes to host cells (Veiga et al. 2007). SRC-mediated phosphorylation of cortactin and the ARP2/3 complex involved in actin polymerization is implicated in CDH1 endocytosis and Listeria monocytogenes internalization (Sousa et al. 2007, Ren et al. 2009)
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source AP2M1 Affinity Capture-MS, tandem affinity purification association, physical 24189400 , (Europe PMC )0.35 BioGRID, IntAct APP Reconstituted Complex physical 21244100 , 21832049 , (Europe PMC )NA BioGRID ARRB2 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 17620599 , (Europe PMC )0.35 BioGRID, IntAct ATF2 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 22304920 , (Europe PMC )0.35 BioGRID, IntAct ATP4A Affinity Capture-MS physical 17255364 , (Europe PMC )NA BioGRID AURKA Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID BMI1 Affinity Capture-MS physical 24457600 , (Europe PMC )NA BioGRID BTRC Affinity Capture-Western physical 27316454 , (Europe PMC )NA BioGRID CCDC8 Affinity Capture-MS physical 24711643 , (Europe PMC )NA BioGRID CDC5L Affinity Capture-MS, anti bait coimmunoprecipitation association, physical 20467437 , (Europe PMC )0.35 BioGRID, IntAct, MINT CDH1 Affinity Capture-Western, Co-crystal Structure, Co-localization, FRET, Proximity Label-MS, Reconstituted Complex, Two-hybrid, fluorescence microscopy, proximity ligation assay, x-ray crystallography colocalization, direct interaction, physical, physical association 10409703 , 12427869 , 12640114 , 12707304 , 19711372 , 20371349 , 21670201 , 22715382 , 22752307 , 22850631 , 23180380 , 24424122 , 25468996 , 7542250 , 7651399 , 7876318 , 9535896 , (Europe PMC )0.27, 0.40, 0.44 BioGRID, IntAct CDH2 Affinity Capture-MS, Affinity Capture-Western, anti bait coimmunoprecipitation physical, physical association 12604612 , 14625392 , 20371349 , 21357690 , (Europe PMC )0.40 BioGRID, IntAct CDH3 Affinity Capture-Western physical 23180380 , 8660921 , (Europe PMC )NA BioGRID CDH5 Affinity Capture-MS, Affinity Capture-Western physical 11855855 , 28514442 , 9378757 , (Europe PMC )NA BioGRID CDH8 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID CEP135 Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct COL17A1 Reconstituted Complex, Two-hybrid physical 10321838 , (Europe PMC )NA BioGRID CSNK1E Affinity Capture-Western physical 21670201 , (Europe PMC )NA BioGRID CTDSPL Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID CTNNA1 Affinity Capture-Western physical 7651399 , (Europe PMC )NA BioGRID CTNNA3 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID CTNNB1 Affinity Capture-Western physical 11712088 , 9535896 , (Europe PMC )NA BioGRID CTTN Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation physical, physical association 12835311 , 17576929 , (Europe PMC )0.40 BioGRID, IntAct CUL3 Affinity Capture-MS physical 21145461 , (Europe PMC )NA BioGRID EGFR Affinity Capture-Luminescence, Affinity Capture-MS, Affinity Capture-Western, PCA, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, tandem affinity purification, ubiquitin reconstruction association, physical, physical association 15657067 , 24189400 , 24658140 , 24797263 , 25402006 , 27316454 , 9535896 , (Europe PMC )0.66 BioGRID, IntAct ERBIN Reconstituted Complex physical 11821434 , (Europe PMC )NA BioGRID FOXB1 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT FYN Affinity Capture-Western, Biochemical Activity physical 12640114 , 12835311 , (Europe PMC )NA BioGRID G3BP1 Affinity Capture-MS physical 26777405 , (Europe PMC )NA BioGRID GSK3B Affinity Capture-Western physical 28069439 , (Europe PMC )NA BioGRID HNRNPL Affinity Capture-RNA physical 28611215 , (Europe PMC )NA BioGRID IFI16 Affinity Capture-MS physical 25693804 , (Europe PMC )NA BioGRID KCTD6 Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 25416956 , (Europe PMC )0.49, 0.56 BioGRID, IntAct KEAP1 Affinity Capture-MS physical 27621311 , (Europe PMC )NA BioGRID LCK Biochemical Activity physical 12835311 , (Europe PMC )NA BioGRID MCM2 Affinity Capture-MS physical 25963833 , (Europe PMC )NA BioGRID MTMR7 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID MUC1 Affinity Capture-Western, Co-localization, Reconstituted Complex physical 11181067 , (Europe PMC )NA BioGRID MYC Affinity Capture-MS, tandem affinity purification association, physical 21150319 , (Europe PMC )0.35 BioGRID, IntAct NTRK1 Affinity Capture-MS physical 25921289 , (Europe PMC )NA BioGRID NXF1 Affinity Capture-RNA physical 22658674 , (Europe PMC )NA BioGRID OTUB1 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26752685 , (Europe PMC )0.35 BioGRID, IntAct PLPP3 Affinity Capture-Western, Far Western, Reconstituted Complex physical 20123964 , (Europe PMC )NA BioGRID PPP4R1 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 , (Europe PMC )0.35 BioGRID, IntAct PSEN1 Affinity Capture-Western, Reconstituted Complex, Two-hybrid physical 10208590 , 28069439 , (Europe PMC )NA BioGRID PTPN6 Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex physical 10835420 , (Europe PMC )NA BioGRID PTPRJ Affinity Capture-Western, Biochemical Activity, biochemical, coimmunoprecipitation, fluorescence technology, pull down colocalization, dephosphorylation reaction, physical, physical association 12370829 , 12475979 , (Europe PMC )0.72 BioGRID, IntAct, MINT PTPRM Affinity Capture-Western, Biochemical Activity physical 10753936 , (Europe PMC )NA BioGRID RIPK3 Affinity Capture-MS physical 21903422 , (Europe PMC )NA BioGRID SNCA Reconstituted Complex physical 18541383 , (Europe PMC )NA BioGRID SOX2 Affinity Capture-MS physical 23667531 , (Europe PMC )NA BioGRID SQSTM1 Affinity Capture-MS, anti tag coimmunoprecipitation physical, physical association 20562859 , (Europe PMC )0.40 BioGRID, IntAct SRC Affinity Capture-Western physical 12640114 , (Europe PMC )NA BioGRID SUMO2 Reconstituted Complex physical 19394292 , (Europe PMC )NA BioGRID TMEM17 Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct TMEM216 Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct VCP Affinity Capture-MS physical 23383273 , (Europe PMC )NA BioGRID WDR48 Affinity Capture-MS, anti tag coimmunoprecipitation physical, physical association 19615732 , (Europe PMC )0.40 BioGRID, IntAct XPO1 Affinity Capture-MS physical 26673895 , (Europe PMC )NA BioGRID YES1 Affinity Capture-Western physical 12640114 , (Europe PMC )NA BioGRID ZBTB33 Affinity Capture-Western, Co-localization, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, two hybrid array, two hybrid prey pooling approach physical, physical association 10207085 , 15548582 , 15564377 , 19615783 , 20382170 , 21670201 , 22276175 , 24498333 , (Europe PMC )0.40, 0.49 BioGRID, IntAct
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source AP2M1 Affinity Capture-MS, tandem affinity purification association, physical 24189400 , (Europe PMC )0.35 BioGRID, IntAct ARRB2 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 17620599 , (Europe PMC )0.35 BioGRID, IntAct ATF2 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 22304920 , (Europe PMC )0.35 BioGRID, IntAct CAMK2D anti tag coimmunoprecipitation association 29426014 , (Europe PMC )0.35 IntAct CDC5L Affinity Capture-MS, anti bait coimmunoprecipitation association, physical 20467437 , (Europe PMC )0.35 BioGRID, IntAct, MINT CDH1 Affinity Capture-Western, Co-crystal Structure, Co-localization, FRET, Proximity Label-MS, Reconstituted Complex, Two-hybrid, fluorescence microscopy, proximity ligation assay, x-ray crystallography colocalization, direct interaction, physical, physical association 10409703 , 12427869 , 12640114 , 12707304 , 19711372 , 20371349 , 21670201 , 22715382 , 22752307 , 22850631 , 23180380 , 24424122 , 25468996 , 7542250 , 7651399 , 7876318 , 9535896 , (Europe PMC )0.27, 0.40, 0.44 BioGRID, IntAct CDH2 Affinity Capture-MS, Affinity Capture-Western, anti bait coimmunoprecipitation physical, physical association 12604612 , 14625392 , 20371349 , 21357690 , (Europe PMC )0.40 BioGRID, IntAct CEP135 Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct CTTN Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation physical, physical association 12835311 , 17576929 , (Europe PMC )0.40 BioGRID, IntAct EGFR Affinity Capture-Luminescence, Affinity Capture-MS, Affinity Capture-Western, PCA, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, tandem affinity purification, ubiquitin reconstruction association, physical, physical association 15657067 , 24189400 , 24658140 , 24797263 , 25402006 , 27316454 , 9535896 , (Europe PMC )0.66 BioGRID, IntAct EZR proximity-dependent biotin identification association 29568061 , (Europe PMC )0.35 IntAct FOXB1 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT FRMD5 anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, fluorescence microscopy association, colocalization, physical association 22846708 , (Europe PMC )0.54 IntAct, MINT HSCB anti bait coimmunoprecipitation association 28380382 , (Europe PMC )0.35 IntAct KCTD6 Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 25416956 , (Europe PMC )0.49, 0.56 BioGRID, IntAct KSR1 anti tag coimmunoprecipitation association 27086506 , (Europe PMC )0.35 IntAct LAMP1 proximity-dependent biotin identification association 29568061 , (Europe PMC )0.35 IntAct MCM7 anti bait coimmunoprecipitation association 23764002 , (Europe PMC )0.35 IntAct MTNR1B tandem affinity purification association 26514267 , (Europe PMC )0.35 IntAct MYC Affinity Capture-MS, tandem affinity purification association, physical 21150319 , (Europe PMC )0.35 BioGRID, IntAct NANOS1 anti bait coimmunoprecipitation, anti tag coimmunoprecipitation physical association 17047063 , (Europe PMC )0.40, 0.52 IntAct OTUB1 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26752685 , (Europe PMC )0.35 BioGRID, IntAct PABPC1 anti bait coimmunoprecipitation, confocal microscopy association, colocalization 28877994 , (Europe PMC )0.43 IntAct PLEKHA7 anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, confocal microscopy, proximity ligation assay association, colocalization, physical association 19041755 , 28877994 , (Europe PMC )0.35, 0.66 IntAct PLPP3 anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, confocal microscopy, far western blotting, pull down colocalization, physical association 20123964 , (Europe PMC )0.64 IntAct PPP4R1 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 , (Europe PMC )0.35 BioGRID, IntAct PTPRJ Affinity Capture-Western, Biochemical Activity, biochemical, coimmunoprecipitation, fluorescence technology, pull down colocalization, dephosphorylation reaction, physical, physical association 12370829 , 12475979 , (Europe PMC )0.72 BioGRID, IntAct, MINT RET anti bait coimmunoprecipitation physical association 21357690 , (Europe PMC )0.40 IntAct SQSTM1 Affinity Capture-MS, anti tag coimmunoprecipitation physical, physical association 20562859 , (Europe PMC )0.40 BioGRID, IntAct TARBP2 anti bait coimmunoprecipitation association 28877994 , (Europe PMC )0.35 IntAct TGOLN2 proximity-dependent biotin identification association 29568061 , (Europe PMC )0.35 IntAct TMEM17 Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct TMEM216 Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct TNRC6A anti bait coimmunoprecipitation association 28877994 , (Europe PMC )0.35 IntAct TUBA1A pull down association 27291054 , (Europe PMC )0.35 IntAct TUBB3 pull down association 27291054 , (Europe PMC )0.35 IntAct WDR48 Affinity Capture-MS, anti tag coimmunoprecipitation physical, physical association 19615732 , (Europe PMC )0.40 BioGRID, IntAct WRAP73 anti tag coimmunoprecipitation association 26545777 , (Europe PMC )0.35 IntAct YAP1 anti bait coimmunoprecipitation association 21376238 , (Europe PMC )0.35 IntAct ZBTB33 Affinity Capture-Western, Co-localization, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, two hybrid array, two hybrid prey pooling approach physical, physical association 10207085 , 15548582 , 15564377 , 19615783 , 20382170 , 21670201 , 22276175 , 24498333 , (Europe PMC )0.40, 0.49 BioGRID, IntAct
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source FOXB1 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT FRMD5 anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, fluorescence microscopy association, colocalization, physical association 22846708 , (Europe PMC )0.54 IntAct, MINT PTPRJ Affinity Capture-Western, Biochemical Activity, biochemical, coimmunoprecipitation, fluorescence technology, pull down colocalization, dephosphorylation reaction, physical, physical association 12370829 , 12475979 , (Europe PMC )0.72 BioGRID, IntAct, MINT
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Interacting partner Detection method Interaction type PubMed IDs Interaction Score Source AGO2 anti bait coimmunoprecipitation, confocal microscopy association, colocalization 28877994 , (Europe PMC )0.43 IntAct AP2M1 Affinity Capture-MS, tandem affinity purification association, physical 24189400 , (Europe PMC )0.35 BioGRID, IntAct APP Reconstituted Complex physical 21244100 , 21832049 , (Europe PMC )NA BioGRID ARRB2 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 17620599 , (Europe PMC )0.35 BioGRID, IntAct ATF2 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 22304920 , (Europe PMC )0.35 BioGRID, IntAct ATP4A Affinity Capture-MS physical 17255364 , (Europe PMC )NA BioGRID AURKA Affinity Capture-MS physical 23443559 , (Europe PMC )NA BioGRID BMI1 Affinity Capture-MS physical 24457600 , (Europe PMC )NA BioGRID BTRC Affinity Capture-Western physical 27316454 , (Europe PMC )NA BioGRID CAMK2D anti tag coimmunoprecipitation association 29426014 , (Europe PMC )0.35 IntAct CCDC8 Affinity Capture-MS physical 24711643 , (Europe PMC )NA BioGRID CDC5L Affinity Capture-MS, anti bait coimmunoprecipitation association, physical 20467437 , (Europe PMC )0.35 BioGRID, IntAct, MINT CDH1 Affinity Capture-Western, Co-crystal Structure, Co-localization, FRET, Proximity Label-MS, Reconstituted Complex, Two-hybrid, fluorescence microscopy, proximity ligation assay, x-ray crystallography colocalization, direct interaction, physical, physical association 10409703 , 12427869 , 12640114 , 12707304 , 19711372 , 20371349 , 21670201 , 22715382 , 22752307 , 22850631 , 23180380 , 24424122 , 25468996 , 7542250 , 7651399 , 7876318 , 9535896 , (Europe PMC )0.27, 0.40, 0.44 BioGRID, IntAct CDH2 Affinity Capture-MS, Affinity Capture-Western, anti bait coimmunoprecipitation physical, physical association 12604612 , 14625392 , 20371349 , 21357690 , (Europe PMC )0.40 BioGRID, IntAct CDH3 Affinity Capture-Western physical 23180380 , 8660921 , (Europe PMC )NA BioGRID CDH5 Affinity Capture-MS, Affinity Capture-Western physical 11855855 , 28514442 , 9378757 , (Europe PMC )NA BioGRID CDH8 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID CEP135 Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct COL17A1 Reconstituted Complex, Two-hybrid physical 10321838 , (Europe PMC )NA BioGRID CSNK1E Affinity Capture-Western physical 21670201 , (Europe PMC )NA BioGRID CTDSPL Proximity Label-MS physical 27880917 , (Europe PMC )NA BioGRID CTNNA1 Affinity Capture-Western physical 7651399 , (Europe PMC )NA BioGRID CTNNA3 Affinity Capture-MS physical 28514442 , (Europe PMC )NA BioGRID CTNNB1 Affinity Capture-Western physical 11712088 , 9535896 , (Europe PMC )NA BioGRID CTTN Affinity Capture-Western, Reconstituted Complex, anti bait coimmunoprecipitation physical, physical association 12835311 , 17576929 , (Europe PMC )0.40 BioGRID, IntAct CUL3 Affinity Capture-MS physical 21145461 , (Europe PMC )NA BioGRID EGFR Affinity Capture-Luminescence, Affinity Capture-MS, Affinity Capture-Western, PCA, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, tandem affinity purification, ubiquitin reconstruction association, physical, physical association 15657067 , 24189400 , 24658140 , 24797263 , 25402006 , 27316454 , 9535896 , (Europe PMC )0.66 BioGRID, IntAct ERBIN Reconstituted Complex physical 11821434 , (Europe PMC )NA BioGRID EZR proximity-dependent biotin identification association 29568061 , (Europe PMC )0.35 IntAct FOXB1 Affinity Capture-MS, tandem affinity purification association, physical 25609649 , (Europe PMC )0.35 BioGRID, IntAct, MINT FRMD5 anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, fluorescence microscopy association, colocalization, physical association 22846708 , (Europe PMC )0.54 IntAct, MINT FYN Affinity Capture-Western, Biochemical Activity physical 12640114 , 12835311 , (Europe PMC )NA BioGRID G3BP1 Affinity Capture-MS physical 26777405 , (Europe PMC )NA BioGRID GSK3B Affinity Capture-Western physical 28069439 , (Europe PMC )NA BioGRID HNRNPL Affinity Capture-RNA physical 28611215 , (Europe PMC )NA BioGRID HSCB anti bait coimmunoprecipitation association 28380382 , (Europe PMC )0.35 IntAct IFI16 Affinity Capture-MS physical 25693804 , (Europe PMC )NA BioGRID KCTD6 Two-hybrid, two hybrid array, two hybrid prey pooling approach, validated two hybrid physical, physical association 25416956 , (Europe PMC )0.49, 0.56 BioGRID, IntAct KEAP1 Affinity Capture-MS physical 27621311 , (Europe PMC )NA BioGRID KSR1 anti tag coimmunoprecipitation association 27086506 , (Europe PMC )0.35 IntAct LAMP1 proximity-dependent biotin identification association 29568061 , (Europe PMC )0.35 IntAct LCK Biochemical Activity physical 12835311 , (Europe PMC )NA BioGRID MCM2 Affinity Capture-MS physical 25963833 , (Europe PMC )NA BioGRID MCM7 anti bait coimmunoprecipitation association 23764002 , (Europe PMC )0.35 IntAct MTMR7 Affinity Capture-MS physical 27432908 , (Europe PMC )NA BioGRID MTNR1B tandem affinity purification association 26514267 , (Europe PMC )0.35 IntAct MUC1 Affinity Capture-Western, Co-localization, Reconstituted Complex physical 11181067 , (Europe PMC )NA BioGRID MYC Affinity Capture-MS, tandem affinity purification association, physical 21150319 , (Europe PMC )0.35 BioGRID, IntAct NANOS1 anti bait coimmunoprecipitation, anti tag coimmunoprecipitation physical association 17047063 , (Europe PMC )0.40, 0.52 IntAct NTRK1 Affinity Capture-MS physical 25921289 , (Europe PMC )NA BioGRID NXF1 Affinity Capture-RNA physical 22658674 , (Europe PMC )NA BioGRID OTUB1 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26752685 , (Europe PMC )0.35 BioGRID, IntAct PABPC1 anti bait coimmunoprecipitation, confocal microscopy association, colocalization 28877994 , (Europe PMC )0.43 IntAct PLEKHA7 anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, confocal microscopy, proximity ligation assay association, colocalization, physical association 19041755 , 28877994 , (Europe PMC )0.35, 0.66 IntAct PLPP3 Affinity Capture-Western, Far Western, Reconstituted Complex physical 20123964 , (Europe PMC )NA BioGRID PLPP3 anti bait coimmunoprecipitation, anti tag coimmunoprecipitation, confocal microscopy, far western blotting, pull down colocalization, physical association 20123964 , (Europe PMC )0.64 IntAct PPP4R1 Affinity Capture-MS, anti tag coimmunoprecipitation association, physical 26496610 , (Europe PMC )0.35 BioGRID, IntAct PSEN1 Affinity Capture-Western, Reconstituted Complex, Two-hybrid physical 10208590 , 28069439 , (Europe PMC )NA BioGRID PTPN6 Affinity Capture-MS, Affinity Capture-Western, Reconstituted Complex physical 10835420 , (Europe PMC )NA BioGRID PTPRJ Affinity Capture-Western, Biochemical Activity, biochemical, coimmunoprecipitation, fluorescence technology, pull down colocalization, dephosphorylation reaction, physical, physical association 12370829 , 12475979 , (Europe PMC )0.72 BioGRID, IntAct, MINT PTPRM Affinity Capture-Western, Biochemical Activity physical 10753936 , (Europe PMC )NA BioGRID RET anti bait coimmunoprecipitation physical association 21357690 , (Europe PMC )0.40 IntAct RIPK3 Affinity Capture-MS physical 21903422 , (Europe PMC )NA BioGRID SNCA Reconstituted Complex physical 18541383 , (Europe PMC )NA BioGRID SOX2 Affinity Capture-MS physical 23667531 , (Europe PMC )NA BioGRID SQSTM1 Affinity Capture-MS, anti tag coimmunoprecipitation physical, physical association 20562859 , (Europe PMC )0.40 BioGRID, IntAct SRC Affinity Capture-Western physical 12640114 , (Europe PMC )NA BioGRID SUMO2 Reconstituted Complex physical 19394292 , (Europe PMC )NA BioGRID TARBP2 anti bait coimmunoprecipitation association 28877994 , (Europe PMC )0.35 IntAct TGOLN2 proximity-dependent biotin identification association 29568061 , (Europe PMC )0.35 IntAct TMEM17 Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct TMEM216 Proximity Label-MS, proximity-dependent biotin identification association, physical 26638075 , (Europe PMC )0.35 BioGRID, IntAct TNRC6A anti bait coimmunoprecipitation association 28877994 , (Europe PMC )0.35 IntAct TUBA1A pull down association 27291054 , (Europe PMC )0.35 IntAct TUBB3 pull down association 27291054 , (Europe PMC )0.35 IntAct VCP Affinity Capture-MS physical 23383273 , (Europe PMC )NA BioGRID WDR48 Affinity Capture-MS, anti tag coimmunoprecipitation physical, physical association 19615732 , (Europe PMC )0.40 BioGRID, IntAct WRAP73 anti tag coimmunoprecipitation association 26545777 , (Europe PMC )0.35 IntAct XPO1 Affinity Capture-MS physical 26673895 , (Europe PMC )NA BioGRID YAP1 anti bait coimmunoprecipitation association 21376238 , (Europe PMC )0.35 IntAct YES1 Affinity Capture-Western physical 12640114 , (Europe PMC )NA BioGRID ZBTB33 Affinity Capture-Western, Co-localization, Reconstituted Complex, Two-hybrid, anti bait coimmunoprecipitation, two hybrid array, two hybrid prey pooling approach physical, physical association 10207085 , 15548582 , 15564377 , 19615783 , 20382170 , 21670201 , 22276175 , 24498333 , (Europe PMC )0.40, 0.49 BioGRID, IntAct
Phosphorylating Kinases Phosphoresidues Detection Method PubMed IDs Source
Visualize a network of protein kinases and phosphatases phosphorylating and dephosphorylating this protein respectively
CSNK1E S268_PQVRVGGsSVDLHRF , NA NA PhosphoSitePlus , EGFR Y228_YPGGSDNyGSLSRVT , in vitro, in vivo 14996911 , 17016520 , 17389395 , 20068231 ,(Europe PMC )HPRD, GSK3B S252_MEGYRAPsRQDVYGP , T310_GTARRTGtPSDPRRR , in vitro, in vivo 12885254 , 18212344 , 20166139 ,(Europe PMC )HPRD, PRKCA S879_LIDRNQKsDKKPDRE , NA NA PhosphoSitePlus , PRKCE S268_PQVRVGGsSVDLHRF , NA NA PhosphoSitePlus , SRC Y112_PGQIVETyTEEDPEG , Y228_YPGGSDNyGSLSRVT , Y257_APSRQDVyGPQPQVR , Y280_HRFHPEPyGLEDDQR , Y291_DDQRSMGyDDLDYGM , Y296_MGYDDLDyGMMSDYG , Y302_DYGMMSDyGTARRTG , Y96_QDHSHLLySTIPRMQ , in vitro, in vivo 11382764 , 14996911 , 17016520 , 17389395 , 18669648 , 18707149 , 20068231 ,(Europe PMC )HPRD, Unknown S122_EDPEGAMsVVSVETS , S129_SVVSVETsDDGTTRR , S131_VSVETSDsGTTRRTE , S143_RTETTVKsVVKTVTT , S151_VVKTVTTsTVQPVAM , S167_PDGLPVDsSSVSNNY , S168_DGLPVDAsSVSNNYI , S187_RDFRKNGsGGPGPYV , S199_PYVGQAGsATLPRNF , S219_GYSRHYEsGYPGGSD , S230_GGSDNYGsLSRVTRI , S232_SDNYGSLsRVTRIEE , S244_IEERYRPsMEGYRAP , S245_EERYRPSsEGYRAPS , S248_YRPSMEGsRAPSRQD , S251_SMEGYRAsSRQDVYG , S252_MEGYRAPsRQDVYGP , S268_PQVRVGGsSVDLHRF , S269_QVRVGGSsVDLHRFH , S288_GLEDDQRsMGYDDLD , S300_DLDYGMMsDYGTARR , S312_ARRTGTPsDPRRRLR , S320_DPRRRLRsYEDMIGE , S346_LAQHERGsLASLDSL , S349_HERGSLAsLDSLRKG , S352_GSLASLDsLRKGGPP , S47_QLERVRVsPQDANPL , S4_MDDsEVESTAS , S568_IVQAEIGsKDSDSKL , S574_GQKDSDSsLVENCVC , S669_PEVVRIYsSLLKESK , S675_YISLLKEsKTPAILE , S704_TYGRYIRsALRQEKA , S710_RSALRQEsALSAIAD , S740_ALRNLAVsARNKELI , S746_VDARNKEsIGKHAIP , S752_ELIGKHAsPNLVKNL , S757_HAIPNLVsNLPGGQQ , S758_AIPNLVKsLPGGQQN , S761_NLVKNLPsGQQNSSW , S763_VKNLPGGsQNSSWNF , S767_PGGQQNSsWNFSEDT , S772_NSSWNFSsDTVISIL , S778_SEDTVISsLNTINEV , S784_SILNTINsVIAENLE , S790_NEVIAENsEAAKKLR , S792_VIAENLEsAKKLRET , S805_ETQGIEKsVLINKSG , S811_KLVLINKsGNRSEKE , S813_VLINKSGsRSEKEVR , S819_GNRSEKEsRAAALVL , S841_ELRKPLEsEGWKKSD , S847_EKEGWKKsDFQVNLN , S853_KSDFQVNsNNASRSQ , S858_VNLNNASsSQSSHSY , S859_NLNNASRsQSSHSYD , S862_NASRSQSsHSYDDST , S864_SRSQSSHsYDDSTLP , S868_SSHSYDDsTLPLIDR , S873_DDSTLPLsDRNQKSD , S879_LIDRNQKsDKKPDRE , S885_KSDKKPDsEEIQMSN , S891_DREEIQMsNMGSNTK , S893_EEIQMSNsGSNTKSL , S914_PNERGDHsRTLDRSG , S920_HNRTLDRsGDLGDME , T203_QAGTATLtRNFHYPP , T209_LPRNFHYtPDGYSRH , T304_GMMSDYGtARRTGTP , T310_GTARRTGtPSDPRRR , T59_NPLMANGtLTRRHQN , T613_NVANNTGtHAASCFG , T619_GPHAASCtGAKKGKD , T714_RQEKALStIADLLTN , T720_SAIADLLtNEHERVV , T762_LVKNLPGtQQNSSWN , T768_GGQQNSStNFSEDTV , T788_TINEVIAtNLEAAKK , T799_AAKKLREtQGIEKLV , T805_ETQGIEKtVLINKSG , T809_IEKLVLItKSGNRSE , T815_INKSGNRtEKEVRAA , T825_EVRAAALtLQTIWGY , T826_VRAAALVtQTIWGYK , T831_LVLQTIWtYKELRKP , T832_VLQTIWGtKELRKPL , T863_ASRSQSStSYDDSTL , T869_SHSYDDStLPLIDRN , T889_KPDREEItMSNMGSN , T900_MGSNTKStDNNYSTP , T906_SLDNNYStPNERGDH , T910_NYSTPNEtGDHNRTL , T916_ERGDHNRtLDRSGDL , T926_RSGDLGDtEPLKGTT , T927_SGDLGDMtPLKGTTP , T932_DMEPLKGtTPLMQDE , T933_MEPLKGTtPLMQDEG , Y107_PRMQEPGyIVETYTE , Y112_PGQIVETyTEEDPEG , Y116_VETYTEEyPEGAMSV , Y120_TEEDPEGyMSVVSVE , Y127_AMSVVSVyTSDDGTT , Y156_TTRTVQPyAMGPDGL , Y174_ASSVSNNyIQTLGRD , Y179_NNYIQTLyRDFRKNG , Y190_RKNGNGGyGPYVGQA , Y195_GGPGPYVyQAGTATL , Y201_VGQAGTAyLPRNFHY , Y208_TLPRNFHyPPDGYSR , Y213_FHYPPDGySRHYEDG , Y217_PDGYSRHyEDGYPGG , Y220_YSRHYEDyYPGGSDN , Y221_SRHYEDGyPGGSDNY , Y228_YPGGSDNyGSLSRVT , Y233_DNYGSLSyVTRIEER , Y257_APSRQDVyGPQPQVR , Y280_HRFHPEPyGLEDDQR , Y291_DDQRSMGyDDLDYGM , Y296_MGYDDLDyGMMSDYG , Y302_DYGMMSDyGTARRTG , Y321_PRRRLRSyEDMIGEE , Y334_EEVPSDQyYWAPLAQ , Y73_NGRFVGDyDLERQKF , Y758_AIPNLVKyLPGGQQN , Y764_KNLPGGQyNSSWNFS , Y797_LEAAKKLyETQGIEK , Y803_LRETQGIyKLVLINK , Y859_NLNNASRyQSSHSYD , Y865_RSQSSHSyDDSTLPL , Y898_SNMGSNTySLDNNYS , Y904_TKSLDNNySTPNERG , Y96_QDHSHLLySTIPRMQ , HTP, in vivo 12885254 , 15951569 , 16083285 , 16212419 , 17016520 , 17081983 , 17389395 , 18083107 , 18212344 , 18220336 , 18452278 , 18491316 , 18578522 , 18669648 , 18707149 , 19413330 , 19415658 , 19651622 , 19664994 , 19664995 , 20058876 , 20068231 , 20166139 ,(Europe PMC )HPRD, PhosphoELM ,
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