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Statistics
241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last update: 11 Mar, 2019
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last update: 11 Mar, 2019
Top
KEGG Pathway - Leukocyte transendothelial migration - Homo sapiens (human) 
 | Phosphatases regulating this pathway |
| Name | UniProt AC | Dephosphorylates following protein substrates: | Dephosphorylates following non-protein substrates: |
| PTPN11 | Q06124 | SPRY2, SPRY1, JAK2, MPZL1, EGFR, PDGFRB, SRC, SELE, IRS1, KDR, STAT1, STAT5A, PXN, STAT5B, SIRPA, ARHGAP5, GAB1, PTK2B, PAG1, GAB2, MAP3K4, ERBB2, LCK, CD28, ERBB2, PDCD1, ERBB4, | Non-protein substrates of this phosphatase are not reported yet |
| Protein substrates in this pathway |
| Name | UniProt AC | Dephosphorylated by: |
| CTNND1 | O60716 | PTPRJ, PTPRM, PTPRT, PTPN6, PTPN1, PTPRK, |
| ITGB1 | P05556 | PPP2CA, PPP2CB, PTP4A3, |
| PRKCB | P05771 | PHLPP1, PHLPP2, PPP1CA, PPP2CA, PPP2CB, |
| ACTN1 | P12814 | PTPN1, PTPN6, |
| EZR | P15311 | PTP4A3, |
| PRKCA | P17252 | PHLPP1, PHLPP2, PPP1CA, PPP1CB, PPP1CC, PPP2CA, PPP2CB, |
| PLCG1 | P19174 | PTPN1, PTPRJ, |
| MSN | P26038 | PPM1A, PPM1B, |
| PIK3R1 | P27986 | PPM1A, PTPRJ, |
| CTNNB1 | P35222 | PTPN23, PTPRF, ACP1, PTPN14, PTPN1, PTPRU, PTPRK, DUSP23, |
| PXN | P49023 | PPP2CA, PPP2CB, PTPRT, PTPN11, |
| VASP | P50552 | PPP2CA, PPP2CB, PPP3CA, PPP3CB, PPP3CC, |
| MAPK12 | P53778 | PTPN3, |
| BCAR1 | P56945 | PPP2CA, PPP2CB, PTP4A3, PTPN1, PTPN12, PTPRA, PTPRH, |
| PTK2 | Q05397 | PTPN23, ACP1, PPP1CA, PPP1CB, PPP1CC, PTEN, PTPN1, PTPN12, UBASH3B, |
| PTPN11 | Q06124 | PTPN1, |
| ARHGAP5 | Q13017 | PTPN11, |
| PTK2B | Q14289 | PTPN12, PTPN11, |
| MAPK14 | Q16539 | DUSP22, DUPD1, PTPN7, DUSP8, DUSP1, DUSP9, DUSP10, DUSP2, PPP2CA, PPP2CB, PPM1A, PPM1D, DUSP26, DUSP3, DUSP14, |
| OCLN | Q16625 | PTPRJ, |
| ARHGAP35 | Q9NRY4 | PTPN18, PTPRZ1, |
| Non-protein substrates in this pathway |
| ChEBI ID | KEGG ID | ChEBIasciiName | Molecule | Dephosphorylated by: |
| CHEBI:18348 | C04637 | 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate |  | FIG4, INPP5B, INPP5E, INPP5J, INPP5K, OCRL, PTP4A3, PTPRQ, INPP5F, SYNJ1, SYNJ2, |