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Statistics
241 human active and 13 inactive phosphatases in total;
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last update: 11 Mar, 2019
194 phosphatases have substrate data;
--------------------------------
336 protein substrates;
83 non-protein substrates;
1215 dephosphorylation interactions;
--------------------------------
299 KEGG pathways;
876 Reactome pathways;
--------------------------------
last update: 11 Mar, 2019
Top
KEGG Pathway - Leishmaniasis - Homo sapiens (human) 
 | Phosphatases regulating this pathway |
| Name | UniProt AC | Dephosphorylates following protein substrates: | Dephosphorylates following non-protein substrates: |
| PTPN6 | P29350 | JAK2, CTNND1, NFAT5, EGFR, ESR1, NTRK1, LCK, LYN, ROS1, KIT, ACTN1, SRC, CD33, CD22, NOS1, HOXA10, KDR, CASP8, GAB2, ERBB2, ERBB4, | Non-protein substrates of this phosphatase are not reported yet |
| TAB1 | Q15750 | Protein substrates of this phosphatase are not reported yet | Non-protein substrates of this phosphatase are not reported yet |
| Protein substrates in this pathway |
| Name | UniProt AC | Dephosphorylated by: |
| MAP3K7 | O43318 | PPP2CA, PPP2CB, PPM1B, PPM1L, PPP6C, |
| JAK2 | O60674 | PTPRC, PTPN1, PTPN6, PTPN11, |
| JUN | P05412 | PPP3CA, PPP3CB, PPP3CC, |
| ITGB1 | P05556 | PPP2CA, PPP2CB, PTP4A3, |
| PRKCB | P05771 | PHLPP1, PHLPP2, PPP1CA, PPP2CA, PPP2CB, |
| FCGR2A | P12318 | ACP1, |
| ELK1 | P19419 | PPP3CA, PPP3CB, PPP3CC, |
| JAK1 | P23458 | PTPRC, PTPN2, |
| NFKBIA | P25963 | PTPN1, PTPN13, PPP3CB, PPP3CC, PPP2CB, PPP2CA, PPP3CA, |
| MAPK3 | P27361 | CDC25A, DUPD1, PTPN7, DUSP5, DUSP1, DUSP4, DUSP9, DUSP23, PTPRE, PTPRJ, DUSP3, PPP2CA, PTPRR, DUSP14, |
| MAPK1 | P28482 | CDC25A, DUSP22, DUPD1, PTPN7, DUSP5, DUSP1, DUSP4, DUSP6, DUSP9, DUSP7, DUSP2, PPP2CA, PPP2CB, PTPRE, PTPRJ, DUSP3, PTPRR, |
| PTPN6 | P29350 | PTPN1, |
| STAT1 | P42224 | PTPN11, PTPN2, |
| MAPK12 | P53778 | PTPN3, |
| RELA | Q04206 | PPP2CA, PPP4C, PPP2CB, |
| MAPK14 | Q16539 | DUSP22, DUPD1, PTPN7, DUSP8, DUSP1, DUSP9, DUSP10, DUSP2, PPP2CA, PPP2CB, PPM1A, PPM1D, DUSP26, DUSP3, DUSP14, |
| Non-protein substrates in this pathway |
Non-protein substrates involved in this pathway are unknown (yet!)